The research in BvK LaB comprises molecular biology, recombinant or native protein production and purification, protein characterization, sample preparation for crystallography, electron microscopy or time-resolved laser absorption spectroscopy, structure modelling, biochemical measurements (enzyme kinetics), and complementary techniques such as cross-linking mass spectrometry, SAXS (Small Angle X-ray Scattering), and CD (Circular Dichroism) Spectroscopy

 

The current research projects are;

 

1. Structural investigation of chaperone and protease complexes that are involved in bacterial membrane protein quality control.

This project is funded by

TUBITAK 2232

International Outstanding Researchers Program

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2. FunTomP (Functionalized Tomato Products) project, funded under Section 1 Agrofood Value Chain of the PRIMA Program, which supports projects on agriculture, food, agro-food chain, and water themes in the Mediterranean Area within the scope of Horizon 2020. In this project,

we will functionalize tomato products with proteins extracted

from sugar beet leaves, a waste of the beet sugar industry.  

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3. Development of HoxA9-Pbx1/3 Protein-Protein Interaction Inhibitors with Anticancer Effect and Peptidomimetic Structure, funded by TÜBİTAK ARDEB 1001 program, in a collaboration with Dr. Hacer Karataş Bristow from Istanbul Medipol University

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4. Production of Membrane Protein Complexes involved in Membrane Protein Translocation and Quality Control funded by TUBİTAK 1002 Program

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5. Structural dynamics and functional studies of nitrogen fixation proteins funded by TUBİTAK 3501 and 1001 Programs

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6. Artificial intelligence based development of peptide inhibitors as potential antibiotics funded by TUBİTAK 2516 Korea Bilateral Cooperation Program, in a collaboration with Seoul National University